Höppener, Diederik J.
Verheul, Sanne M. L. https://orcid.org/0000-0001-6070-6337
Nierop, Pieter M. H.
Buisman, Florian E.
Galjart, Boris
Wilting, Saskia M. https://orcid.org/0000-0002-2838-841X
Pugh, Siân A.
Richman, Susan D. https://orcid.org/0000-0003-3993-5041
Balachandran, Vinod P. https://orcid.org/0000-0002-2956-223X
Jarnagin, William R.
Kingham, T. Peter
Vermeulen, Peter B.
Shia, Jinru https://orcid.org/0000-0002-4351-2511
Quirke, Philip https://orcid.org/0000-0002-3597-5444
Bridgewater, John A.
Maughan, Timothy S. https://orcid.org/0000-0002-0580-5065
Groot Koerkamp, Bas
Grünhagen, Dirk J. https://orcid.org/0000-0001-8293-6002
Verhoef, Cornelis
Primrose, John N. https://orcid.org/0000-0002-2069-7605
D’Angelica, Michael I.
,
Quirke, Philip
Funding for this research was provided by:
Cancer Research UK
Article History
Received: 9 December 2024
Revised: 28 May 2025
Accepted: 24 June 2025
First Online: 23 July 2025
Competing interests
: The authors declare no competing interests.
: All methods were performed in accordance with the relevant guidelines and regulations. Institutional ethical review was obtained from the medical ethics committee of the Erasmus University Medical Center, Rotterdam, the Netherlands (MEC-2018-1743). MSKCC: All the patients signed a clinical (IRB #16-1343 or #15-044) or research (IRB #12-245) consent form for genomic sequencing. New EPOC: The study was approved by the South West Research Ethics Committee, and data were reviewed by the data monitoring and ethics committee. All patients provided written informed consent for further research on their samples during trial enrolment.