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Authors
Novitski, Sif Ingibergsdóttir
Jacobsen, Rikke Louise
Röder, Timo
Holm, Peter Christoffer
Schwinn, Michael https://orcid.org/0000-0002-6151-369X
Vejborg, Ilse https://orcid.org/0000-0002-2329-203X
von Euler-Chelpin, My Catarina
Lynge, Elsebeth
Ostrowski, Sisse R. https://orcid.org/0000-0001-5288-3851
Sørensen, Erik https://orcid.org/0000-0002-5002-9077
Pedersen, Ole Birger https://orcid.org/0000-0003-2312-5976
Erikstrup, Christian
Aagaard, Bitten https://orcid.org/0000-0001-8306-1332
Hjalgrim, Henrik https://orcid.org/0000-0002-4436-6798
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Ostrowski, Sisse Rye
Pedersen, Ole Birger
Erikstrup, Christian
Jensen, Bitten Aagaard
Hjalgrim, Henrik
Rafnar, Thórunn
Stefansson, Kari
Ullum, Henrik
Banasik, Karina
Brunak, Søren
Rafnar, Thórunn
Stefansson, Kari
Mavaddat, Nasim
Ficorella, Lorenzo https://orcid.org/0000-0002-0577-1571
Antoniou, Antonis C.
Ullum, Henrik
Banasik, Karina
Brunak, Søren https://orcid.org/0000-0003-0316-5866
Bojesen, Stig Egil https://orcid.org/0000-0002-4061-4133
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Funding
Funding for this research was provided by:
Research Council of the Capital Region of Denmark
Novo Nordisk Fonden (NNF17OC0027594)
Novo Nordisk Fonden (NNF17OC0027594)
Novo Nordisk Fonden (NNF14CC0001)
Novo Nordisk Fonden (NNF20SA0064340)
Cancer Research UK (grant number PPRPGM-Nov20\100002)
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Article History
Received: 25 February 2025
Revised: 29 September 2025
Accepted: 17 October 2025
First Online: 12 November 2025
Competing interests
: ACA and LF are listed as creators of the BOADICEA model, which has been licensed from Cambridge Enterprise (University of Cambridge) for commercial purposes. SB has ownerships in Intomics A/S, Hoba Therapeutics Aps, Novo Nordisk A/S, Lundbeck A/S, ALK abello A/S, Eli Lilly and Co and managing board memberships in Proscion A/S and Intomics A/S. All other authors declare no competing interests.
: All authors consented to publication of this manuscript.
: All DBDS participants gave informed consent. All methods were performed in accordance with the relevant guidelines and regulations. This study was approved by the National Committee on Health Research Ethics (M-20090237/1-10-72-95-13, NVK-1700407 and SJ-740) and the data protection in the Capital Region of Denmark (P-2019-99).
