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Authors
van Megesen, Kyah https://orcid.org/0000-0003-0870-788X
Stefan, Arianna
Kieboom, Madelief
Amico, Rebecca
Jansen, Anne M. L.
Borel Rinkes, Inne
Kranenburg, Onno https://orcid.org/0000-0002-2112-4390
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Funding
Funding for this research was provided by:
KWF Kankerbestrijding (13435)
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Article History
Received: 27 November 2024
Revised: 6 October 2025
Accepted: 3 December 2025
First Online: 5 January 2026
Competing interests
: The authors declare no competing interests.
: All patients provided informed consent to their tumor tissues being used for PMDO generation and subsequent molecular and genetic analysis. PDMO samples have been collected with patient consent as part of the CRC-PIPAC studies (NCT03246321, NL8303), Interact trial (NCT06003998), or unpublished collaboration (ORCAPM) between UMC Utrecht and Catharina Hospital Eindhoven. Which all have been approved by the Medical Review Ethics Committee (NL60405.100.17, R19.087, NL81672.100.22, ORCA-PM-CZE). The studies were performed in accordance with the Declaration of Helsinki.
