Turnham, Daniel J. https://orcid.org/0000-0002-2540-7363
French, Rhiannon
Frame, Fiona M.
Meniel, Valerie S.
Maitland, Norman J.
Clarkson, Richard W. E.
Funding for this research was provided by:
Prostate Cancer UK (RIA15-ST2-016)
Prostate Cancer UK (RIA15-ST2-016)
The Wallscourt Foundation
Cancer Research Wales (2450)
Cancer Research Wales (2494)
Article History
Received: 4 June 2025
Revised: 19 January 2026
Accepted: 10 February 2026
First Online: 3 March 2026
Competing interests
: The authors declare no competing interests.
: The use of human samples was performed in accordance with the Declaration of Helsinki. Patient samples were collected with ethical permission from Castle Hill Hospital (Ethics Number: 07/H1304/121) and the Wales Cancer Biobank (Project Number: 16007). Use of patient tissue was approved by the Local Research Ethics Committees. Patients gave informed consent and all patient samples were anonymized. Animal work was approved by the Cardiff University, School of Biosciences ethics committee and performed under UK Home Office licence PP1361991 following ARRIVE 2.0 and NC3R guidelines