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Authors
Mavaddat, Nasim https://orcid.org/0000-0003-0307-055X
Barnes, Daniel R. https://orcid.org/0000-0002-3781-7570
Michailidou, Kyriaki https://orcid.org/0000-0001-7065-1237
Zhao, Emily
Frost, Debra
Leslie, Goska https://orcid.org/0000-0001-5756-6222
Dennis, Joe https://orcid.org/0000-0003-4591-1214
Wang, Qin
Bolla, Manjeet K.
,
Ahmed, Munaza
Barwell, Julian
Brady, Angela F.
Brennan, Paul
Conti, Hector
Cook, Jackie
Copeland, Harriet
Davidson, Rosemarie
Donaldson, Alan
Gallagher, David
Hart, Rachel
Izatt, Louise
Kanani, Farah
Kemp, Zoe
Lalloo, Fiona
Miedzybrodzka, Zosia
Morrison, Patrick J.
Murray, Jennie E.
Murray, Alex
Musgrave, Hannah
Searle, Claire
Side, Lucy
Snape, Katie
Tripathi, Vishakha
Walker, Lisa
Evans, D. Gareth https://orcid.org/0000-0002-8482-5784
Tischkowitz, Marc
Thompson, Deborah J.
Perry, John R. B. https://orcid.org/0000-0001-6483-3771
Antoniou, Antonis C.
Easton, Douglas F. https://orcid.org/0000-0003-2444-3247
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Article History
Received: 11 April 2025
Revised: 22 December 2025
Accepted: 19 February 2026
First Online: 30 March 2026
Competing interests
: Since completing the work described in this paper, Deborah Thompson has left the University of Cambridge and is now employed by Genomics Ltd. JRBP is an employee/shareholder of Insmed Innovation UK / Insmed, receives research funding from GSK and consultancy fees from WW International and Ovartix. All other authors report no conflict of interest.
: The EMBRACE study was approved by the East of England—Cambridge South Ethics Committee (ref 98/5/026, IRAS 20971). All patients gave written informed consent. Each participating study in CIMBA and BCAC obtained informed consent from the participants and was approved by the appropriate institutional ethics review board or committee. The research conformed to the principles of the Helsinki Declaration.
: All authors read and approved the final version of the manuscript and consent to publication
