Ichikawa, Tomonaga https://orcid.org/0000-0002-0679-5866
Shimosaki, Shunsuke
Nakahata, Shingo
Suekane, Akira
Kitabayashi, Issay
Iha, Hidekatsu
Shimoda, Kazuya https://orcid.org/0000-0002-2555-8188
Murakami, Takashi https://orcid.org/0000-0001-9772-2613
Morishita, Kazuhiro
Funding for this research was provided by:
MEXT | Japan Society for the Promotion of Science (Grant-in Aid for Research [C] 15K08310)
MEXT | Japan Society for the Promotion of Science (Grant-in Aid for Research [C] 24K10339)
Takeda Science Foundation
Science Research Promotion Fund of the Promotion and Mutual Aid Corporation for Private Schools of Japan
Article History
Received: 19 May 2025
Revised: 4 January 2026
Accepted: 30 January 2026
First Online: 16 February 2026
Competing interests
: TM has financial interests in Denka Co., Ltd. SS, SN, AS, IK, HI, KS, KM, and TI declare no competing interests in this article.
: It was approved by the Institutional Review Board of the Faculty of Medicine, University of Miyazaki (Approval Code: 972, Approval Data: January 17, 2001), and the Ethical Committee of Saitama Medical University (Approval Code: 2023-013, Approval Data: July 11, 2023). ATL cells were collected from the patients at the time of hospital admission before chemotherapy was initiated with informed consent. All animal experiments were approved by The Animal Experiment Review Board of the University of Miyazaki (Approval Code: 2017-503, Approval Data: 1 April 2017) and the Institutional Animal Care and Use Committee of Saitama Medical University (Approval Code: 3836, Approval Data: 6 December 2023), and was carried out in strict accordance with the recommendations in the Guidelines for Proper Conduct of Animal Experiments (Science Council of Japan, 1 June 2006).