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Authors
Koessinger, Anna L. https://orcid.org/0000-0002-9216-0954
Cloix, Catherine
Koessinger, Dominik https://orcid.org/0000-0002-9739-9323
Heiland, Dieter Henrik https://orcid.org/0000-0002-9258-3033
Bock, Florian J. https://orcid.org/0000-0002-1133-1767
Strathdee, Karen
Kinch, Kevin https://orcid.org/0000-0003-3296-6830
Martínez-Escardó, Laura
Paul, Nikki R.
Nixon, Colin https://orcid.org/0000-0002-8085-2160
Malviya, Gaurav https://orcid.org/0000-0003-0736-7991
Jackson, Mark R. https://orcid.org/0000-0003-3843-2995
Campbell, Kirsteen J. https://orcid.org/0000-0002-0201-8736
Stevenson, Katrina
Davis, Sandeep
Elmasry, Yassmin
Ahmed, Asma https://orcid.org/0000-0002-7194-5701
O’Prey, Jim
Ichim, Gabriel https://orcid.org/0000-0002-8386-7405
Schnell, Oliver
Stewart, William
Blyth, Karen https://orcid.org/0000-0002-9304-439X
Ryan, Kevin M. https://orcid.org/0000-0002-1059-9681
Chalmers, Anthony J. https://orcid.org/0000-0002-1746-7278
Norman, Jim C. https://orcid.org/0000-0002-0098-3014
Tait, Stephen W. G. https://orcid.org/0000-0001-7697-132X
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Article History
Received: 12 April 2021
Revised: 31 March 2022
Accepted: 4 April 2022
First Online: 26 April 2022
Competing interests
: KJC is a recipient of a share in royalty payments paid to the Walter and Eliza Hall Institute of Medical Research in relation to venetoclax. DHH received reimbursement of travel expenses from 10X and the MILO laboratory is part of the 10X VEP program. The other authors declare no competing interests.
: Human samples used for IHC: GBM specimens were obtained from surplus tumour tissue resected from patients treated within the OPARATIC study (NCT01390571). Patients had consented for use of surplus tissue for future research projects. Ex vivo brain tumour slice culture: Fresh GBM tissues were obtained from surplus surgical resection tissue from patients at the Queen Elizabeth University Hospital (QEUH) in Glasgow upon written informed patient consent and after review by neuropathology in accordance with the NHS GG&C ethical committee review (Biorepository Application No. 432). Spatial transcriptomic analysis and tumour single cell RNA seq: GBM specimen collection and data analysis were carried out in accordance with the approved guidelines by the University of Freiburg ethics committee and written informed consent obtained from all patients (protocol 100020/09 and 472/15_160880). All mouse experiments were carried out in accordance with the Animals Act 1986 (Scientific Procedures on living animals) and the regulatory guidelines of the EU Directive 2010 under project licences PPL P4A277133 and PP6345023 and ethical review (University of Glasgow).
