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Authors
He, Wenyan
Li, Yan
Fan, Junwan
Liu, Yang
Yuan, Meng
Cheng, Si
Huang, Xinying
Yan, Bo https://orcid.org/0009-0006-1487-3437
Zhang, Zhuoran
Xiu, Yuwen
Zhu, Huimin
Lan, Tian
Chang, Zhilin
Jiang, Yong
Li, Hao
Meng, Xia
Wang, Yilong
Van Kaer, Luc https://orcid.org/0000-0001-5275-2309
Verkhratsky, Alexei
Wang, Yongjun
Shi, Fu-Dong https://orcid.org/0000-0002-9675-4637
Jin, Wei-Na https://orcid.org/0000-0002-2196-9078
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Funding
Funding for this research was provided by:
National Natural Science Foundation of China (82122021)
National Natural Science Foundation of China (82371353)
National Natural Science Foundation of China (82320108007)
Beijing Municipal Science and Technology Commission (Z241100009024046)
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Article History
Received: 23 August 2024
Revised: 10 April 2025
Accepted: 30 April 2025
First Online: 21 May 2025
Competing interests
: LVK is a member of the scientific advisory board of Isu Abxis Co., Ltd. (Republic of Korea). The other authors declare no competing interests.
: The whole-genome sequencing data utilized in this study were derived from the CNSR-III cohort, with ethical approval granted by the Institutional Review Board of Beijing Tiantan Hospital (approval number: KY2015-001-01). Written informed consents were obtained from all participating patients prior to their inclusion in this study. All animal experiments were conducted in accordance with the ARRIVE (Animal Research: Reporting of in vivo Experiments) guidelines and were performed under protocols approved by the Institutional Animal Care and Use Committee of Beijing Tiantan Hospital (201902026).
