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Authors
Dreute, Jan https://orcid.org/0000-0002-4708-2678
Stengel, Julia https://orcid.org/0009-0000-1014-7290
Becher, Jonas https://orcid.org/0009-0001-6765-6958
van den Borre, David https://orcid.org/0009-0001-2759-6006
Pfisterer, Maximilian https://orcid.org/0000-0003-3573-906X
Bartkuhn, Marek https://orcid.org/0000-0001-6872-9082
Beutgen, Vanessa M. https://orcid.org/0000-0002-3354-2020
Ndreshkjana, Benardina https://orcid.org/0000-0002-4434-3158
Gärtner, Ulrich
Graumann, Johannes https://orcid.org/0000-0002-3015-5850
Huck, Michael https://orcid.org/0009-0004-5691-575X
Klatt, Stephan https://orcid.org/0000-0003-0064-3367
Leff, Chloe https://orcid.org/0000-0002-9036-4099
Farin, Henner F. https://orcid.org/0000-0003-1558-5366
Nist, Andrea
Schmitz, Roland https://orcid.org/0000-0002-3348-6807
Stiewe, Thorsten https://orcid.org/0000-0003-0134-7826
Teply-Szymanski, Julia https://orcid.org/0000-0002-3880-1968
Wilhelm, Jochen https://orcid.org/0000-0001-5544-9647
Cabrera-Orefice, Alfredo https://orcid.org/0000-0002-2042-3794
Schmitz, M. Lienhard https://orcid.org/0000-0002-6984-7192
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Article History
Received: 27 February 2025
Revised: 9 May 2025
Accepted: 3 June 2025
First Online: 23 June 2025
Competing interests
: The authors declare no competing interests.
: All methods were performed in accordance with the local/institutional guidelines and European regulations. Tonsil tissue was provided by the department of Otolaryngology, Head and Neck Surgery of the University Hospital of Giessen and Marburg. Tonsil experiments were approved under license AZ37/20 from the institutional ethics committee of the Justus Liebig University Giessen with prior written informed consent from patients/parents/guardians. Human colorectal cancer organoids were provided by the University Cancer Center Frankfurt (UCT). All materials were collected as part of the interdisciplinary Biobank and Database Frankfurt (iBDF), with prior written informed consent from patients. The study received approval from the institutional review board of the UCT and the Ethical Committee at the University Hospital Frankfurt (ethics vote: 4/09; project number: SGI-10-2022).
