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Authors
Wang, Qian https://orcid.org/0000-0002-5196-4972
Tjokrodirijo, Rayman T. N.
Mei, Hailiang
van Veelen, Peter A.
ten Dijke, Peter https://orcid.org/0000-0002-7234-342X
Fan, Chuannan https://orcid.org/0000-0001-8754-4913
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Funding
Funding for this research was provided by:
ZonMW grant
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Article History
Received: 18 April 2025
Revised: 17 September 2025
Accepted: 9 October 2025
First Online: 27 October 2025
Competing interests
: The authors declare no competing interests.
: All zebrafish studies were conducted in a licensed establishment for the breeding and use of experimental animals (at Leiden University). The Institutional Committee for Animal Welfare of the Leiden University Medical Center (LUMC) approved this study. We strictly adhered to internal regulations and guidelines. Advice from the LUMC committee for Animal Welfare was followed to minimize suffering within the facility. The zebrafish assays described do not fall under the definition of an animal experiment according to the Experiments on Animals Act (Wod, effective 2014), the applicable legislation in the Netherlands, in compliance with European guidelines (EU directive 2010/63/EU) on the protection of animals used for scientific purposes. Since non-self-feeding larvae were used, no specific license was required for these assays on zebrafish larvae (<5 days post-fertilization). No human participants or specimens were involved in this study.
