Zema, Sabrina https://orcid.org/0000-0002-7966-5923
Di Fazio, Francesca
Pelullo, Maria
Di Savino, Sara
Cerbelli, Bruna
Leopizzi, Martina
Di Magno, Laura
Nicoletti, Carmine https://orcid.org/0000-0001-5896-2040
Peruzzi, Giovanna https://orcid.org/0000-0002-6517-9107
D’Andrea, Daniel
Giuli, Maria V.
Cialfi, Samantha
Palmisano, Biagio https://orcid.org/0000-0002-1287-5256
Turdo, Alice https://orcid.org/0000-0002-6152-4903
Palermo, Rocco
d’Amati, Giulia https://orcid.org/0000-0002-6959-691X
Canettieri, Gianluca
Faggiano, Antongiulio
Di Marcotullio, Lucia https://orcid.org/0000-0003-0274-7178
Todaro, Matilde
Screpanti, Isabella https://orcid.org/0000-0001-8071-9098
Talora, Claudio https://orcid.org/0000-0002-6973-2184
Checquolo, Saula https://orcid.org/0000-0001-5109-8392
Bellavia, Diana https://orcid.org/0000-0001-5728-2537
Article History
Received: 13 February 2025
Revised: 29 September 2025
Accepted: 27 October 2025
First Online: 21 November 2025
Competing interests
: The authors declare no competing interests.
: Human samples for IHC analysis were obtained with informed consent of patients, and all experimental procedures were performed following guidelines from Sapienza University of Rome—Policlinico Umberto I (RIF.CE: 5639). All animal experiments were approved by local ethic authorities (Ministry of Health) and performed in accordance with Italian Governing Law (D.Lgs. n.26/2014/ Protocol Number: C1368.17 and C1368.22) and European Directive 2010/63/UE for the care and use of animals to protect them for experimental and other scientific purposes.