Huang, Yanmei
Gao, Pengyue
Luo, Li
Bai, Yuxin
Wang, Weijiayi
Jiang, Panpan
Zhang, Xin
Lai, Juan
Liu, Ju
Chang, Jiang
Dai, Xin
Luo, Xi
Guan, Fei
Miller, Heather
Du, Xingrong https://orcid.org/0000-0001-6427-9600
Lei, Jiahui
Yang, Lu
Liu, Chaohong https://orcid.org/0000-0001-7028-4625
Funding for this research was provided by:
Ministry of Science and Technology of the People's Republic of China (2021YFE0108200)
National Natural Science Foundation of China (NSFC32311530061, 31970839 and 32100709)
Article History
Received: 6 November 2024
Revised: 2 November 2025
Accepted: 2 December 2025
First Online: 23 December 2025
Competing interests
: Xin Zhang and Juan Lai were hired from GeneMind Biosciences Company Limited, Shenzhen, China. Heather Miller was from Cytek Biosciences, R&D Clinical Reagents, Fremont, CA, United States. The rest of the authors have no competing interests.
: All animal experiments were approved by the Animal Experiment System Protection and Ethics Committee of Tongji Medical College (Wuhan, China) and were conducted in strict accordance with relevant guidelines and regulations. All clinical trials were approved by the Wuhan Children’s Hospital Committee for Research Ethics (No. 2024R062) and informed consent was obtained from all human participants prior to the study. All experiments complied with the Declaration of Helsinki.