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Authors
Yi, Xiaoyan https://orcid.org/0000-0001-6995-8573
Martin-Vazquez, Eugenia https://orcid.org/0000-0003-4881-4938
Jawurek, Sayro https://orcid.org/0009-0002-4821-5935
L. Zimath, Priscila
Garcia Oliveira, Junior https://orcid.org/0000-0002-3971-126X
Costa-Junior, Jose Maria
Ilegems, Erwin
Wesley, Johnna D. https://orcid.org/0000-0002-3693-1101
C. Title, Alexandra
Yesildag, Burcak
Eizirik, Decio L. https://orcid.org/0000-0003-2453-5889
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Article History
Received: 19 June 2025
Revised: 9 December 2025
Accepted: 21 January 2026
First Online: 30 January 2026
Competing interests
: SJ and ACT are employees of InSphero AG, a company commercializing human islets microtissues and related services. BY is a member of the management team of InSphero AG., DLE is a member of the Scientific Advisory Board of InSphero AG. EI and JDW are or were employees of Novo Nordisk A/S.
: Ethical approval was not required for this study as we used publicly available datasets and an established cell line, i.e., EndoC-βH1. The hIsMTs were from an anonymised and cadaveric organ donor and informed consent was obtained at the isolation site according to local ethical legislation.
