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Article History

Received: 15 November 2020

Accepted: 22 March 2021

First Online: 12 April 2021

Funding

: This study is supported by the funds from the National Natural Science Foundation of China (81974021, 81974012, 81720108003 and 81670285), the National Key R&D Program of China (No. 2018YFC1002400), Shanghai Natural Science Foundation (20ZR1435500), Translational Medicine Cross-Research Fund of Shanghai Jiao Tong University (ZH2018ZDA10). Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine (17YJJ28).

: All animal studies were undertaken in accordance with German Animal Welfare legislation and with the European Communities Council Directive 2010/63/EU for the protection of animals used for experimental purposes. All experiments were approved by the Local Institutional Animal Care and Research Advisory Committee and permitted by the relevant local authority for animal protection. The study was conducted in accordance with the Declaration of Helsinki, and the protocols used to collect human samples of blood and aborted embryos were approved by the Medical Ethics Committee of Xinhua Hospital. Written informed consents were also obtained from all subjects prior to inclusion in the study.

: The authors declare no competing interests.