Fernández-Tussy, Pablo https://orcid.org/0000-0002-7263-6767
Rodríguez-Agudo, Rubén https://orcid.org/0000-0001-5731-5052
Fernández-Ramos, David
Barbier-Torres, Lucía
Zubiete-Franco, Imanol
Davalillo, Sergio López de
Herraez, Elisa
Goikoetxea-Usandizaga, Naroa
Lachiondo-Ortega, Sofia https://orcid.org/0000-0003-1856-3664
Simón, Jorge
Lopitz-Otsoa, Fernando https://orcid.org/0000-0001-8452-6939
Juan, Virginia Gutiérrez-de
McCain, Misti V.
Perugorria, Maria J.
Mabe, Jon
Navasa, Nicolás
Rodrigues, Cecilia M. P. https://orcid.org/0000-0002-4829-754X
Fabregat, Isabel https://orcid.org/0000-0003-0136-8440
Boix, Loreto
Sapena, Victor
Anguita, Juan https://orcid.org/0000-0003-2061-7182
Lu, Shelly C. https://orcid.org/0000-0003-2128-5407
Mato, José M. https://orcid.org/0000-0003-1264-3153
Banales, Jesus M.
Villa, Erica https://orcid.org/0000-0001-6388-7022
Reeves, Helen L.
Bruix, Jordi
Reig, Maria
Marin, Jose J. G. https://orcid.org/0000-0003-1186-6849
Delgado, Teresa C.
Martínez-Chantar, María L. https://orcid.org/0000-0002-6446-9911
Article History
Received: 9 January 2021
Revised: 3 May 2021
Accepted: 10 May 2021
First Online: 28 May 2021
Ethics statement
: All patients in the study gave informed consent to all clinical investigations, according to the principles embodied in the Declaration of Helsinki. The project was approved by participating institutions. For Animal research, CIC bioGUNE’s Animal Care and Use Committee and the competent authority (Diputación de Bizkaia) approved the animal procedures.
: J.M.M. consults for, advises for, and owns stock in Owl. He consults for and advises Abbott. He consults for Galmed. M.L.M.-C. consults and advises for Mitotherapeutix LLC. J.B.: consultancy from Arqule, Bayer, Novartis, BMS, BTG-Biocompatibles, Eisai, Kowa, Terumo, Gilead, Bio-Alliance/Onxeo, Roche, AbbVie, Merck, Sirtex, Ipsen, Astra-Medimmune, Incyte, Quirem, Adaptimmune, Lilly, Basilea, Nerviano. Research grants from Bayer and BTG. Educational grants from Bayer and BTG. Lecture fees from Bayer, BTG-Biocompatibles, Eisai, Terumo, Sirtex, Ipsen. M.R.: consultancy from Bayer, BMS, Roche, Ipsen, AstraZeneca, and Lilly. Lecture fees from Bayer, BMS, Gilead, Roche, and Lilly. Research grants from Bayer and Ipsen. V.S.: travel grants from Bayer Dr. Banales reports grants from INCYTE, personal fees for lecturer from BAYER and INTERCEPT, and consulting for QED Therapeutics, Albireo Pharma and OWL METABOLOMICS, outside the submitted work. The rest of the authors have nothing to disclose.