Article History
Received: 9 May 2021
Revised: 26 August 2021
Accepted: 9 September 2021
First Online: 17 December 2021
Competing interests
: The authors declare no competing interests.
: All participants from China-Japan Union Hospital of Jilin University or their guardians provided signed informed consent prior to enrollment. The Ethics Committee of China-Japan Union Hospital of Jilin University provided Ethical Approval for the experiments involving human being in this study, which conformed to the Declaration of Helsinki. Animal experiments were ratified by Animal Ethics Committee of China-Japan Union Hospital of Jilin University in accordance with the animal ethics standards expressed in the Care and Use of Laboratory Animals published by the US National Institutes of Health. Extensive efforts were made to minimize suffering of the included animals.