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Targeting of histone methyltransferase DOT1L plays a dual role in chemosensitization of retinoblastoma cells and enhances the efficacy of chemotherapy

Crossref DOI link: https://doi.org/10.1038/s41419-021-04431-y

Published Online: 2021-12-09

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Mao, Yu

Sun, Yu

Wu, Zhixuan

Zheng, Jingzhi

Zhang, Jianing

Zeng, Jiaqi

Lee, Chunsik https://orcid.org/0000-0002-8151-7196
Kim, Jong Kyong https://orcid.org/0000-0001-7930-723X
Funding

Funding for this research was provided by:

National Natural Science Foundation of China (81572764)

Guangdong Provincial Research Fund
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Article History

Received: 9 July 2021

Revised: 16 November 2021

Accepted: 25 November 2021

First Online: 9 December 2021

Ethics approval and consent to participate

: The study with human clinical samples conformed to the standards set by the Declaration of Helsinki, and was approved by the ZOC institutional review board (2018KYPJ004). All human specimens used for this study were de-identified, and written informed consent forms were obtained. All animal studies were reviewed and approved by the Sun Yat-sen University Institutional Animal Care and Use Committee (2018-001A).

: The authors declare no competing interests.

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