Krawetz, Roman J. http://orcid.org/0000-0002-2576-4504
Wu, Yiru Elizabeth
Bertram, Karri L.
Shonak, Anchita http://orcid.org/0000-0003-1196-6452
Masson, Anand O.
Ren, Guomin
Leonard, Catherine
Kapoor, Mohit
Matyas, John R. http://orcid.org/0000-0001-6318-0115
Salo, Paul T. http://orcid.org/0000-0002-4005-9758
Funding for this research was provided by:
Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada (RGPIN-2014-04586)
Canada Foundation for Innovation (JELF)
Gouvernement du Canada | Canadian Institutes of Health Research (01309MOP-311542-DIB-CBBA-170939)
Article History
Received: 23 August 2021
Revised: 3 May 2022
Accepted: 5 May 2022
First Online: 18 May 2022
Competing interests
: The authors declare no competing interests.
: Human and animals ethics approval was obtained from the University of Calgary to carry out the work presented in this study. Informed consent to participate was obtained by written agreement. The study protocol was approved by the University of Calgary Research Ethics Board (University of Calgary ethics # 21987). Animal studies were carried out in accordance with the recommendations in the Canadian Council on Animal Care Guidelines and approved by the University of Calgary Health Sciences Animal Care Committee (AC20-0042). All sample sizes were based on previous published studies. Animals were assigned to groups based on sex to equalize M vs. F as much as possible and the investigators were not blinded to the groupings.