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Authors
Xu, Guojie https://orcid.org/0000-0002-2091-3558
Zhao, Lei https://orcid.org/0000-0003-2876-4347
Hua, Qingling https://orcid.org/0000-0002-4708-987X
Wang, Lanqing
Liu, Hongli
Lin, Zhenyu
Jin, Min
Wang, Jing
Zhou, Pengfei
Yang, Kunyu
Wu, Gang https://orcid.org/0000-0001-6558-3508
Yu, Dandan https://orcid.org/0000-0003-2578-7324
Zhang, Dejun https://orcid.org/0000-0002-8623-5075
Zhang, Tao https://orcid.org/0000-0003-4018-3393
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Funding
Funding for this research was provided by:
National Natural Science Foundation of China (81702392)
National Natural Science Foundation of China (81872429)
National Natural Science Foundation of China (82272711)
National Natural Science Foundation of China (81903103)
National Natural Science Foundation of China (81874061)
University Natural Science Research Project of Anhui Province (2022AH051132)
Natural Science Foundation of Hubei Province (2019CFB147)
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Article History
Received: 20 September 2022
Accepted: 2 February 2023
First Online: 27 February 2023
Competing interests
: The authors declare no competing interests.
: Animal studies were conducted in compliance with all relevant ethical regulations. Animal studies and Clinical trials performed at Union Hospital, Tongji Medical college, Huazhong University of Science and Technology and were approved by the Union Hospital Institutional Animal Care, Animal Use Committee, and Medical Ethics Committee. Each Clinical trial was conducted in accordance with the Declaration of Helsinki and the International Conference on Harmonization Good Clinical Practice guidelines. An independent data and safety monitoring committee proved oversight of efficacy and safety.
