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The TRPV1-PKM2-SREBP1 axis maintains microglial lipid homeostasis in Alzheimer’s disease

Published Online: 2025-01-14

Authors

Sha, Xudong

Lin, Jiayuan

Wu, Kexin

Lu, Jia

Yu, Zhihua https://orcid.org/0000-0003-4993-0199
Funding

Funding for this research was provided by:

National Natural Science Foundation of China (82173791)

Science and Technology Commission of Shanghai Municipality (23ZR1436600)
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Text and Data Mining valid from 2025-01-14

Version of Record valid from 2025-01-14
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Article History

Received: 13 July 2024

Revised: 8 December 2024

Accepted: 27 December 2024

First Online: 14 January 2025

Competing interests

: The authors declare no competing interests.

: Human postmortem tissues from control and AD patients were obtained from the Netherlands Brain Bank (Netherlands Institute for Neuroscience, Amsterdam, Netherlands), with written informed consent for the use of brain autopsy specimens in research obtained premortem. Ethical approval for the animal study (Ethics Protocol Number: A-2023-123) was obtained from the Animal Care and Use Committee of Shanghai Jiao Tong University School of Medicine, Shanghai, China.

: All authors have provided informed consent for publication of this study.

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