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Targeted demethylation of the EphA7 promoter inhibits tumorigenesis via the SP1/DNMT1 and PI3K/AKT axes and improves the response to multiple therapies in cervical cancer

Crossref DOI link: https://doi.org/10.1038/s41419-025-07512-4

Published Online: 2025-04-21

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Zhang, Wenfan

Zhao, Jing

Fan, Xueting

Chen, Shuang

Wang, Rong https://orcid.org/0000-0003-3502-5446
Funding

Funding for this research was provided by:

Natural Science Foundation of Tianjin City (23JCYBJC00230)
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Text and Data Mining valid from 2025-04-21

Version of Record valid from 2025-04-21
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Article History

Received: 5 July 2024

Revised: 11 February 2025

Accepted: 10 March 2025

First Online: 21 April 2025

Competing interests

: The authors declare no competing interests.

: Ethical approval was not required for this study as it utilized data from publicly available databases, including The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO), and human-derived cell lines (HEK293T, CaSki, SiHa, H8) were commercialized. All data and samples were anonymized and ethically sourced, complying with international ethical standards.

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