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LL37 complexed to double-stranded RNA induces RIG-I-like receptor signalling and Gasdermin E activation facilitating IL-36γ release from keratinocytes

Crossref DOI link: https://doi.org/10.1038/s41419-025-07537-9

Published Online: 2025-03-22

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Keller, Jennifer https://orcid.org/0009-0006-0417-4237
Danis, Judit https://orcid.org/0000-0002-0270-5309
Krehl, Isabella https://orcid.org/0009-0002-2370-8186
Girousi, Eleftheria

Satoh, Takashi K. https://orcid.org/0000-0002-6064-9253
Meier-Schiesser, Barbara https://orcid.org/0000-0003-2807-5066
Kemény, Lajos https://orcid.org/0000-0002-2119-9501
Széll, Márta https://orcid.org/0000-0002-0730-714X
Wong, W. Wei-Lynn https://orcid.org/0000-0003-3155-1211
Pascolo, Steve https://orcid.org/0000-0003-2946-5576
French, Lars E. https://orcid.org/0000-0002-4629-1486
Kündig, Thomas M. https://orcid.org/0000-0003-3863-8766
Mellett, Mark https://orcid.org/0000-0002-6315-167X
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Text and Data Mining valid from 2025-03-22

Version of Record valid from 2025-03-22
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Article History

Received: 2 November 2024

Revised: 19 February 2025

Accepted: 13 March 2025

First Online: 22 March 2025

Competing interests

: The authors declare no competing interests.

: Skin biopsies, from which primary keratinocytes were extracted, were collected with informed written consent upon approval from the Kantonale Ethikkommission Zürich (2015-0198 and 2021-00958) and all methods were conducted according to the Declaration of Helsinki Principles.

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