Yamazaki, Reiji https://orcid.org/0000-0001-8052-6624
Azuma, Morio
Osanai, Yasuyuki
Kouki, Tom
Inagaki, Takeshi https://orcid.org/0000-0002-8720-2654
Kakita, Akiyoshi
Takao, Masaki
Ohno, Nobuhiko
Funding for this research was provided by:
Takeda Science Foundation
Uehara Memorial Foundation
Daiwa Securities Health Foundation
Japan Agency for Medical Research and Development (#JP21wm0425019 to M.T. and A.K.,, #JP24zf0127012 to A.K., and #JP24wm0624321 to R.Y.)
Kobayashi Foundation, National Center of Neurology and Psychiatry (NCNP), IDDI Outstanding Basic and Applied Neuroscience Talent Award
MEXT | Japan Society for the Promotion of Science
National Center of Neurology and Psychiatry
Article History
Received: 30 September 2024
Revised: 31 March 2025
Accepted: 4 April 2025
First Online: 13 April 2025
Competing interests
: The authors declare no competing interests.
: All experiments for the clinical study were approved by the Ethical Committee of Jichi Medical University (approval number 23-088), NCNP (approval numbers A2021-126, XXXX-307 and A2023-114), and Niigata University (approval number C2023-0090). All animal experiments were performed in accordance with the Animal Research: Reporting In Vivo Experiments guidelines. All efforts were made to use only the number of animals necessary. All experiments were approved by the Institutional Animal Care and Use Committee at Jichi Medical University (approval number 22047-01) and performed in accordance with the guidelines on the care and use of animals of this committee.