Xie, Xiaozhou
Zhao, Yulong
Liu, Jin
Li, Han
Zhu, Xingyu
Liu, Yuan
Sang, Yaodong
Xu, Kang
Du, Fengying https://orcid.org/0000-0002-2767-1301
Ren, Huicheng
Cui, Xiaoling
Cai, Baoshan
Chen, Hao
Wu, Nanping
Hou, Guihua
Jing, Changqing https://orcid.org/0000-0002-3933-3721
Chong, Wei https://orcid.org/0000-0002-1074-8595
Li, Leping
Shang, Liang https://orcid.org/0009-0004-4089-7657
Funding for this research was provided by:
National Natural Science Foundation of China (82203854)
Taishan Scholar Foundation of Shandong Province (No.tsqn202408363, No.tsqn202306373)
China Postdoctoral Science Foundation (2022M711970)
the Key Research and Development Program of Shandong Province
Article History
Received: 5 October 2024
Revised: 17 June 2025
Accepted: 11 July 2025
First Online: 7 August 2025
Competing interests
: The authors declare no competing interests.
: All operations of this study were approved by the Ethics Committee of Shandong Provincial Hospital Affiliated to Shandong First Medical University (NSFC: NO.2022-875) and the Animal Ethics Committee of Shandong First Medical University Affiliated Provincial Hospital (NSFC: NO.2022-875). All methods were performed in accordance with the relevant guidelines and regulations.
: All co-authors have consented to the version of the manuscript for publication.