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FGF15/FGFR4 signaling suppresses M1 macrophage polarization and multi-organ inflammation in septic mice by inhibiting H3K18 lactylation-driven Irf7 expression through NF2-Hippo activation

Crossref DOI link: https://doi.org/10.1038/s41419-025-07962-w

Published Online: 2025-08-19

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Li, Bo

Li, Jiayu

Zhu, Zexiang

Tang, Yong

Zhou, Yun

Du, Geshu

Li, Xing https://orcid.org/0000-0002-5020-4584
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Text and Data Mining valid from 2025-08-19

Version of Record valid from 2025-08-19
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Article History

Received: 12 February 2025

Revised: 8 July 2025

Accepted: 11 August 2025

First Online: 19 August 2025

Competing interests

: The authors declare no competing interests.

: All animal protocols were approved by the Changsha Hospital of Traditional Chinese Medicine (Changsha No. 8 Hospital) committee (the approval number:2023110804) and followed the ARRIVE guidelines (Animal Research: Reporting of In Vivo Experiments) and the Guide for the Care and Use of Laboratory Animals.

: All authors have read and approved the publication of the manuscript.

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