Ning, Meng
Hoshii, Takayuki https://orcid.org/0000-0002-5418-1981
Nakagawa, Takuya
Usui, Genki
Izumi, Shintaro
Hayashi, Kanako
Matsumoto, Makoto https://orcid.org/0009-0006-5365-8975
Rahmutulla, Bahityar
Fukuyo, Masaki
Abe, Hiroyuki
Ushiku, Tetsuo
Kaneda, Atsushi
Funding for this research was provided by:
MEXT | Japan Society for the Promotion of Science (JP22H03099, JP22H04684, JP22K19538, JP24K02516, JPJSCCA20200006)
Takeda Medical Research Foundation
NOVARTIS Foundation (Japan) for the Promotion of Science (NOVARTIS Foundation
Kobayashi Foundation for Cancer Research
Uehara Memorial Foundation
Japan Agency for Medical Research and Development (JP23ama221118, JP25ama221144, JP22zf0127008)
MEXT | Japan Science and Technology Agency (JPMJSP2109)
MEXT | JST | Strategic International Collaborative Research Program (JP22ama221411, JP23jm0210107)
Chiba University IAAR Research Support Program
Article History
Received: 2 December 2024
Revised: 24 July 2025
Accepted: 14 August 2025
First Online: 23 August 2025
Competing interests
: The authors declare no competing interests.
: All the clinical specimens were approved by the Ethical Review Committee of the University of Tokyo Hospital (approval number: G3521-(21)). Informed consent was obtained from all the patients. All methods were performed in accordance with the relevant guidelines and regulations of Chiba University and Japan.