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The combination of venetoclax with dimethyl fumarate synergistically induces apoptosis in AML cells by disrupting mitochondrial integrity through ROS accumulation

Crossref DOI link: https://doi.org/10.1038/s41419-025-08040-x

Published Online: 2025-10-21

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Kawaguchi, Shin-ichiro https://orcid.org/0009-0007-2497-4095
Sato, Kazuya https://orcid.org/0000-0003-2876-4224
Izawa, Junko

Takayama, Norihito

Hayakawa, Hiroko

Tominaga, Kaoru https://orcid.org/0000-0001-8799-528X
Endo, Hitoshi

Kouki, Tom

Ohno, Nobuhiko

Kanda, Yoshinobu
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Text and Data Mining valid from 2025-10-21

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Article History

Received: 13 November 2024

Revised: 2 August 2025

Accepted: 4 September 2025

First Online: 21 October 2025

Competing interests

: The authors of this manuscript have no conflict of interest to disclose as described by Cell Death and Disease.

: All experimental protocols were approved by the ethics committee of Jichi Medical University. The work presented in this paper does not involve research using human participants or animal models.

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