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The deubiquitination enzyme USP14 promotes the tumourigenesis of gastric cancer by enhancing c-MYC nuclear translocation through deubiquitination of KPNA2

Crossref DOI link: https://doi.org/10.1038/s41419-025-08065-2

Published Online: 2025-10-21

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Li, Jia

Tang, Houyi

Chang, Hongbo

Du, Yi

Du, Liang

Zhao, Erhu https://orcid.org/0000-0001-5606-5450
Funding

Funding for this research was provided by:

Natural Science Foundation of Chongqing (CSTB2022NSCQ-MSX0631)
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Text and Data Mining valid from 2025-10-21

Version of Record valid from 2025-10-21
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Article History

Received: 24 March 2025

Revised: 31 July 2025

Accepted: 10 September 2025

First Online: 21 October 2025

Competing interests

: The authors declare no competing interests.

: All experiments involving cancer patients’ samples were obtained from Chaoying Biotechnology Co., Ltd. (Henan, China), and the studies were approved by the Medical Ethics Committee of Tongxu County People’s Hospital of Henan Province. All of the patients were informed consent. Animal welfare and experimental procedures were carried out in accordance with the Guide for the Care and Use of Laboratory Animals and approved by the animal ethics committee of Southwest University.

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