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Authors
Danzi, Federica https://orcid.org/0009-0001-1078-0966
Butera, Giovanna
Sutton, Damien
Perricone, Matthew D.
Hu, Yushu
Celesia, Adriana
Manfredi, Marcello
Brandi, Jessica https://orcid.org/0000-0003-1643-7023
Pourmandi, Narges
Nelson, Noah S.
Lin, Lin
Bevere, Michele https://orcid.org/0000-0001-8778-0860
Pacchiana, Raffaella
Pea, Antonio
Salvia, Roberto
Scarpa, Aldo https://orcid.org/0000-0003-1678-739X
Luchini, Claudio
Cecconi, Daniela https://orcid.org/0000-0002-7314-8941
Ugel, Stefano https://orcid.org/0000-0002-6639-7608
Lyssiotis, Costas A. https://orcid.org/0000-0001-9309-6141
Fiore, Alessandra https://orcid.org/0009-0001-0141-2862
Donadelli, Massimo https://orcid.org/0000-0001-9224-9230
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Funding
Funding for this research was provided by:
Associazione Italiana per la Ricerca sul Cancro (27080)
Associazione Italiana per la Ricerca sul Cancro (29829)
Associazione Italiana per la Ricerca sul Cancro (28054)
Associazione Italiana per la Ricerca sul Cancro (26343)
Associazione Italiana per la Ricerca sul Cancro (21509)
Associazione Italiana per la Ricerca sul Cancro (28730)
Ministero dell'Istruzione, dell'Università e della Ricerca (MNESYS PE00000006)
Ministero dell'Istruzione, dell'Università e della Ricerca (2022CMMRWA)
Ministero dell'Istruzione, dell'Università e della Ricerca (CN00000041)
Ministero dell'Istruzione, dell'Università e della Ricerca (PE00000019)
Ministero dell'Istruzione, dell'Università e della Ricerca (Excellence Project 2023-2027)
U.S. Department of Health & Human Services | NIH | National Cancer Institute (R37CA237421)
U.S. Department of Health & Human Services | NIH | National Cancer Institute (R01CA248160)
U.S. Department of Health & Human Services | NIH | National Cancer Institute (R01CA244931)
Ministero della Salute (PNC-E3-2022-23683266 PNCHLS-DA)
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Article History
Received: 31 March 2025
Revised: 21 August 2025
Accepted: 15 September 2025
First Online: 27 October 2025
Competing interests
: In the past 3 years, CAL has consulted for Astellas Pharmaceuticals, Odyssey Therapeutics, Third Rock Ventures, and T-Knife Therapeutics, and is an inventor on patents pertaining to Kras regulated metabolic pathways, redox control pathways in pancreatic cancer, and targeting the GOT1-ME1 pathway as a therapeutic approach (US Patent No: 2015126580-A1, 05/07/2015; US Patent No: 20190136238, 05/09/2019; International Patent No: WO2013177426-A2, 04/23/2015).
: All animal experiments were approved by Animal Welfare Organization (OPBA) ( ) and conducted according to the guidelines of Federation of European Laboratory Animal Science Association (FELASA).
