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Necrotic and apoptotic adipocytes in the hypoxic tumor microenvironment supply triglycerides to induce cisplatin resistance in the metastatic lymph nodes of head and neck carcinoma

Crossref DOI link: https://doi.org/10.1038/s41419-025-08239-y

Published Online: 2025-11-24

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Li, Feiran https://orcid.org/0000-0003-1478-8305
Huang, Huiying

Huang, Qiang https://orcid.org/0000-0002-5455-9454
Mao, Xinhui

Cong, Ning

Zhuang, Wenjie https://orcid.org/0000-0001-9670-2610
Hsueh, Chi-Yao https://orcid.org/0000-0002-9679-7098
Zhang, Ming https://orcid.org/0000-0003-2909-8446
Funding

Funding for this research was provided by:

National Natural Science Foundation of China (82273097, 82203727)

Natural Science Foundation of Shanghai (23ZR1409700)

Shanghai Municipal Key Clinical Specialt

Shanghai Sailing Program
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Text and Data Mining valid from 2025-11-24

Version of Record valid from 2025-11-24
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Article History

Received: 25 September 2024

Revised: 10 October 2025

Accepted: 3 November 2025

First Online: 24 November 2025

Competing interests

: The authors declare no competing interests.

: All methods were performed in accordance with the relevant guidelines and regulations.

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