Yang, Shiguang
Liu, Shaoqing
Li, Jie
Mao, Shengwei
Yu, Qifeng https://orcid.org/0000-0001-9953-988X
Zhao, Xuhui
Wu, Xiaoling
Chen, Jiafeng
Bu, Yichao https://orcid.org/0009-0002-1283-3547
Liu, Weiren https://orcid.org/0000-0003-3393-1322
Fang, Yuan https://orcid.org/0009-0006-7342-4877
Shi, Yinghong https://orcid.org/0000-0002-1833-8988
Article History
Received: 22 March 2025
Revised: 8 October 2025
Accepted: 3 November 2025
First Online: 24 November 2025
Competing interests
: The authors declare no competing interests.
: Relevant clinical data and specimens utilized in this study were anonymized prior to analysis, all experimental procedures were conducted in strict accordance with relevant guidelines and regulations, including the principles outlined in the Declaration of Helsinki. All patients provided written informed consent prior to enrollment under a protocol approved by the Clinical Research Ethics Committee of Zhongshan Hospital, Fudan University (No. B2021-143R). All mouse experiments obtained approval from the Experimental Animal Ethics Committee of Zhongshan Hospital, Fudan University(No.20220120-068), and conducted in accordance with the NIH Guide for the Care and Use of Laboratory Animals.