Cui, Qixiao
Zhou, Xiaolin
Chen, Xiaojie
Zhao, Xiaochuan
Zhang, Rui
Wang, Jince
Li, Xiaoli
Wang, Guoli
Li, Bohan
Li, Minjing https://orcid.org/0000-0001-9276-4654
Chen, Jiajia
Gao, Xihang
Shi, Yanbing
Li, Wenting
Hong, Pan https://orcid.org/0000-0001-7262-278X
Li, Defang https://orcid.org/0000-0003-4151-9151
Article History
Received: 11 July 2024
Revised: 2 November 2025
Accepted: 4 December 2025
First Online: 18 December 2025
Competing interests
: The authors declare no competing interests.
: Animal experiment protocols were approved by the ethics committee of the Animal Ethics Committee of Binzhou Medical College (2022-375). Tissue microarrays were obtained from Shanghai Qutdo Biotech Company. The study protocol was approved by Shanghai Qutdo Biotech Company Ethics Committee (SHYJS-CP-2004002 and SHYJS-CP-1407004). All experiments were performed in compliance with the relevant regulations, and all patients provided written informed consent.