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Authors
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Funding
Funding for this research was provided by:
Department of Education of Shandong Province (2020KJK002)
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Article History
Received: 10 August 2025
Revised: 11 November 2025
Accepted: 4 December 2025
First Online: 7 March 2026
Competing interests
: The authors declare no competing interests.
: All experimental procedures were conducted in strict accordance with relevant guidelines and regulations, including the principles outlined in the Declaration of Helsinki. All patients provided written informed consent prior to enrollment under a protocol approved by the Research Ethics Committee of BinZhou Medical University, China (No. KYLL-2022-165). All mouse experiments obtained approval from the Experimental Animal Ethics Committee of BinZhou Medical University, China (No. 20221014-101), and conducted in accordance with the NIH Guide for the Care and Use of Laboratory Animals.
