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Selenomethionine as a dual-mechanism ferroptosis inhibitor: selenium-supply-driven GPX4 biosynthesis beyond transsulfuration and reductive-capacity-mediated ROS scavenging independent of GPX4 activity

Crossref DOI link: https://doi.org/10.1038/s41419-026-08466-x

Published Online: 2026-02-14

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Xia, Chaoyi

Sun, Xue

Shao, Junyi

Min, Jingshu

Wei, Chong

Zhao, Feiyang

Fu, Caiyun https://orcid.org/0000-0003-4090-885X
Zhang, Qiang https://orcid.org/0000-0001-8728-6109
Funding

Funding for this research was provided by:

Zhejiang Sci-Tech University (24042191-Y)

Natural Science Foundation of Zhejiang Province (LQN25C070001)

Natural Science Foundation of Zhejiang Province ((LD22H310004)
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Text and Data Mining valid from 2026-02-14

Version of Record valid from 2026-02-19
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Article History

Received: 21 March 2025

Revised: 19 December 2025

Accepted: 30 January 2026

First Online: 14 February 2026

Competing interests

: The authors declare no competing interests.

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