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α-ketoglutarate/succinate ratio imbalance impairs thymine DNA glycosylase function and base excision repair process increasing susceptibility to pancreatic cancer

Crossref DOI link: https://doi.org/10.1038/s41419-026-08475-w

Published Online: 2026-02-21

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Malatesta, Silvia

Vigiano Benedetti, Virginia

Salviati, Emanuela

Illi, Barbara

Manni, Isabella

Middonti, Emanuele

Rampioni Vinciguerra, Gian Luca https://orcid.org/0000-0003-0739-1668
Licursi, Valerio https://orcid.org/0000-0002-8172-1437
Troilo, Francesca

Colotti, Gianni https://orcid.org/0000-0002-9913-0635
Cipolla, Lina

Sabbioneda, Simone

Perfetto, Livia

Piaggio, Giulia https://orcid.org/0000-0003-2114-1892
Bussolino, Federico https://orcid.org/0000-0002-5348-1341
Di Nicolantonio, Federica https://orcid.org/0000-0001-9618-2010
Campiglia, Pietro

Sommella, Eduardo Maria https://orcid.org/0000-0001-8654-6431
Mori, Mattia

Cencioni, Chiara https://orcid.org/0000-0001-6284-539X
Spallotta, Francesco https://orcid.org/0000-0002-0466-6286
Funding

Funding for this research was provided by:

Associazione Italiana per la Ricerca sul Cancro (23099)

Associazione Italiana per la Ricerca sul Cancro (28858)

Associazione Italiana per la Ricerca sul Cancro (22910)

Ministero dell'Istruzione, dell'Università e della Ricerca (P2022E3BTH)

Ministero dell'Istruzione, dell'Università e della Ricerca (2022HYF8KS)

Ministero dell'Istruzione, dell'Università e della Ricerca (P2022R7WRC)

Sapienza Università di Roma (Ateneo Grande 2023)
License Information

Text and Data Mining valid from 2026-02-21

Accepted Manuscript valid from 2026-02-21
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Article History

Received: 4 September 2025

Revised: 27 January 2026

Accepted: 9 February 2026

First Online: 21 February 2026

Competing interests

: The authors declare no competing interests.

: All methods were performed in accordance with the relevant guidelines and regulations. All animal studies were approved by the Institutional Animal Care of Regina Elena National Cancer Institute (Rome, Italy) and by the Government Committee of National Minister of Health (protocol permit number: 362/2021-PR) and conducted according to EU Directive 2010/63/EU and Italian D.L. 2614/2014 for animal experiments following the Institutional Guidelines for Animal Care and Welfare. The present study does not include human subjects.

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