Karnan, Sivasundaram https://orcid.org/0000-0003-2165-7565
Ota, Akinobu https://orcid.org/0000-0002-6296-2921
Hasan, Muhammad Nazmul https://orcid.org/0000-0003-2536-7557
Murakami, Hideki
Rahman, Md. Lutfur
Wahiduzzaman, Md https://orcid.org/0000-0001-5915-8935
Shihan, Md Towhid Ahmed
Jahan, Nushrat
Vu, Lam Quang
Hanamura, Ichiro https://orcid.org/0000-0002-6681-8927
Inoko, Akihito https://orcid.org/0000-0002-6739-2948
Riku, Miho
Ito, Hideaki
Kaneko, Yoshifumi
Lin, Yinzhi
Hyodo, Toshinori
Konishi, Hiroyuki https://orcid.org/0000-0003-1131-4905
Tsuzuki, Shinobu
Hosokawa, Yoshitaka
Funding for this research was provided by:
Ministry of Education, Culture, Sports, Science and Technology (19K09292, 22K08985,22K08985)
Ministry of Education, Culture, Sports, Science and Technology (21K08426)
Article History
Received: 11 February 2025
Revised: 7 January 2026
Accepted: 10 February 2026
First Online: 28 February 2026
Competing interest
: This publication has no conflicts of interest, and there has been no substantial financial support for this work that could have influenced its outcome. The manuscript has been reviewed and endorsed by all named authors, and there are no other individuals who meet the criteria for authorship but are not listed. All authors have consented to the order in which they are listed in the manuscript.
: The authors declare no competing interests.
: The research conducted adhered to the ethical standards outlined by the Japanese Ministry of Health, Labour, and Welfare. All methods were performed in accordance with the relevant guidelines and regulations. All animal experiments were conducted in accordance with the protocols (approval number-2022-20) approved by the ethical committee of Aichi Medical University and followed established guidelines.