Ren, Anwen https://orcid.org/0000-0002-9244-3559
Feng, Nan
Yang, Tinglin https://orcid.org/0009-0008-2504-4591
Tang, Zimei
Liu, Huan
Li, Yi
Hu, Qingyi
Xi, Zihan
Zhu, Jiaqing
Zhou, Jun
Ming, Jie
Liu, Nan
Huang, Tao https://orcid.org/0000-0003-2130-8621
Funding for this research was provided by:
National Natural Science Foundation of China (82303518)
National Natural Science Foundation of China (82503810)
National Natural Science Foundation of China (82403712)
National Natural Science Foundation of China (82404027)
National Natural Science Foundation of China (82270830)
National Natural Science Foundation of China (82573420)
Natural Science Foundation of Hubei Province (2022CFB072)
Natural Science Foundation of Shandong Province (ZR2022MH156)
Article History
Received: 27 August 2025
Revised: 27 January 2026
Accepted: 26 February 2026
First Online: 11 March 2026
Competing interests
: The authors declare no competing interests.
: The study of human tissues was performed in accordance with the and was authorized by the Ethics Committee of Union Hospital of Huazhong University of Science and Technology [2025(0424-01)]. Written informed consent was obtained from all patients in this sturdy. The animal experiments were performed under the administration of Institution of Animal Care and Use Committee, Huazhong University of Science and Technology ([2024] 4416).