Villa, Genaro R. https://orcid.org/0000-0001-9461-2291
Alimonti, Paolo https://orcid.org/0009-0009-8359-9314
Toker, Joseph S.
Piranlioglu, Raziye https://orcid.org/0000-0003-2450-3887
Karkoski, Mikayla A.
Mazzetti, Debora
Ben Mrid, Reda https://orcid.org/0000-0001-6342-7405
El Guendouzi, Sara
Lauinger, Alexa
Chiocca, Andrew N.
El Fatimy, Rachid
Chiocca, E. Antonio https://orcid.org/0000-0001-5183-1670
Mineo, Marco https://orcid.org/0000-0001-7608-4579
Funding for this research was provided by:
Neurosurgery Research and Education Foundation
U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (T32GM144273)
Article History
Received: 17 June 2025
Revised: 6 February 2026
Accepted: 6 March 2026
First Online: 24 March 2026
Competing interests
: The authors declare no competing interests.
: All methods were performed in accordance with the relevant guidelines and regulations. Tumor tissue samples and patient-derived cell lines were obtained as approved by the IRB at the Dana-Farber Cancer Institute (Protocol No: 10-417), and informed consent was obtained from all participants. All animal experiments were conducted in accordance with protocols approved by the Institutional Animal Care and Use Committee (IACUC) at the Brigham and Women’s Hospital (Protocol No: 2024N000132 and 2016N000383).