Sun, Hao https://orcid.org/0009-0008-9332-2469
Yang, Chenxiao
Du, Juntong
Xu, Chao
Chen, Yao
Chen, Jinsuo
Yue, Nanxi
Gong, Ruining
Yang, Zhan https://orcid.org/0000-0001-7191-2910
Funding for this research was provided by:
National Natural Science Foundation of China (No. 82472667)
Taishan Scholar Foundation of Shandong Province (NO. tsqn202312380)
Natural Science Foundation of Shandong Province (ZR2025MS1491)
China higher education Innovation Fund project
Article History
Received: 31 October 2025
Revised: 7 February 2026
Accepted: 6 March 2026
First Online: 28 March 2026
Competing interests
: The authors declare no competing interests.
: All methods in this study were performed in accordance with the relevant guidelines and regulations. The study involving human participants was reviewed and approved by the Ethics Committee of the Affiliated Hospital of Qingdao University (Permission No. QYFYWZLL28017). All patients provided written informed consent prior to participation. All animal experimental procedures were approved by the Committee for the Care and Use of Laboratory Animals at the Affiliated Hospital of Qingdao University (Permission No. AHQU-MAL20201016) and were carried out in compliance with the Guide for the Care and Use of Laboratory Animals (National Research Council).