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Stattic enhances the anti-tumor activity of AZD4547 in LUSC by blocking STAT3/RRM2-mediated DNA repair and inducing ROS-driven mitochondrial dysfunction

Crossref DOI link: https://doi.org/10.1038/s41419-026-08848-1

Published Online: 2026-05-19

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Wang, Jiehong

Hao, Yue

Wang, Ke https://orcid.org/0000-0003-3812-7018
Lu, Naiyan

Zhu, Xue

Fang, Jing

Shu, Hong

Wang, Xun https://orcid.org/0000-0003-0916-3634
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Text and Data Mining valid from 2026-05-19

Accepted Manuscript valid from 2026-05-19
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Article History

Received: 2 October 2025

Revised: 9 April 2026

Accepted: 30 April 2026

First Online: 19 May 2026

Competing interests

: The authors declare no competing interests.

: The procedures for care and use of animals were approved by the Laboratory Animal Ethics Committee of Jiangsu Institute of Nuclear Medicine (JSINM-2024-163) and all applicable institutional and governmental regulations concerning the ethical use of animals were followed.

: All authors are consent for publication.

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