Otani, Yoshinori https://orcid.org/0000-0002-3214-4637
Zhu, Xiaowei
Liu, Xinlang
Koga, Kohei
Kawabata, Ryo
Miyajima, Hisao
Takumi, Toru https://orcid.org/0000-0001-7153-266X
Fujitani, Masashi https://orcid.org/0000-0002-1731-9793
Funding for this research was provided by:
MEXT | Japan Society for the Promotion of Science (23K07290)
MEXT | Japan Society for the Promotion of Science (22K07868)
Shimane University (Shimane University Hospital Foundation for the Promotion of Advanced Medical Care)
MEXT | Japan Science and Technology Agency
Article History
Received: 23 December 2025
Revised: 17 April 2026
Accepted: 7 May 2026
First Online: 19 May 2026
Competing interests
: The authors declare no competing interests.
: All animal protocols were approved by the Department of Experimental Animals, Interdisciplinary Center for Science Research, Head Office for Research and Academic Information, Shimane University (approval numbers IZ4-4 and IZ7-12).
: During the preparation of this work, the author(s) used Gemini and PaperPal to improve the language and clarity of the manuscript. After using this tool/service, the author(s) reviewed and edited the content as needed and take(s) full responsibility for the content of the publication.