Yano, Kimiyoshi
Kato, Megumi
Endo, Syoju
Igarashi, Taichi
Wada, Ryoga
Kohno, Takashi https://orcid.org/0000-0002-5371-706X
Zimmermann, Astrid
Dahmen, Heike
Zenke, Frank T.
Shiotani, Bunsyo https://orcid.org/0000-0002-3583-4318
Article History
Received: 9 August 2024
Revised: 18 December 2024
Accepted: 16 January 2025
First Online: 28 January 2025
Competing interests
: Astrid Zimmermann and Heike Dahmen are employees of the healthcare business of Merck KGaA, Darmstadt, Germany. Frank T. Zenke was an employee of the healthcare business of Merck KGaA, Darmstadt, Germany, at the time of the study. Bunsyo Shiotani received research grants from the healthcare business of Merck KGaA, Darmstadt, Germany (CrossRef Funder ID: 10.13039/100009945). The remaining authors declare no conflicts of interest.
: All methods in this study were performed in accordance with relevant guidelines and regulations. Animal experiments were approved by the National Cancer Center Research Institute Committee for Ethics of Animal Experimentation (approval number: T21-011-M02). All procedures were conducted in accordance with institutional and national ethical guidelines for animal research.