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Targeting iron regulatory protein 2 (IRP2) to disrupt iron metabolism enhances radiosensitivity through mitochondrial dysfunction in breast cancer cells

Crossref DOI link: https://doi.org/10.1038/s41420-025-02653-z

Published Online: 2025-07-31

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Jeong, Ye Yeong https://orcid.org/0009-0008-5294-4536
Hwang, Jieon

Park, Areum https://orcid.org/0000-0001-9086-7617
Cho, Sungmin

Cho, Inyoung

Won, Soseul

Shin, You Me https://orcid.org/0009-0004-2613-8515
Kim, Sung Eun

Maeng, Chan Hoon

Yang, Jaemoon

Ku, Minhee

Lee, Hyuk https://orcid.org/0000-0002-5791-3826
Shin, Sang Joon https://orcid.org/0000-0001-5350-7241
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Text and Data Mining valid from 2025-07-31

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Article History

Received: 12 January 2025

Revised: 24 June 2025

Accepted: 15 July 2025

First Online: 31 July 2025

Competing interests

: The authors declare no competing interests.

: Ethical approval for the animal experiments was granted by the Institutional Animal Care and Use Committee (IACUC) under approval number 2024-0009. Animal models were sourced from OrientBio, Inc. and maintained in specific pathogen-free conditions with unrestricted access to food and water. All experimental procedures were performed in accordance with relevant institutional guidelines and regulations.

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