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Combination of HDAC inhibitor and PI3K inhibitor suppresses autophagy and induces apoptosis via cytoplasmic IκBα stabilization in p53-mutant diffuse large B-cell lymphoma

Crossref DOI link: https://doi.org/10.1038/s41420-025-02756-7

Published Online: 2025-10-06

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Yao, Jingwei

Li, Mengqi

Jiang, Yuelong

Yao, Nanye

Liu, Yating

Lv, Liemei

Li, Yuchen

Huang, Jiewen

Zha, Jie https://orcid.org/0000-0001-9376-3450
Xu, Bing https://orcid.org/0000-0003-4273-5462
Funding

Funding for this research was provided by:

National Natural Science Foundation of China (U22A20290, 82170180, 82470187)

Xiamen Municipal Bureau of Science and Technology (3502Z20234001, 3502Z20227346, 3502Z202372076)
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Text and Data Mining valid from 2025-10-06

Version of Record valid from 2025-10-06
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Article History

Received: 21 May 2025

Revised: 14 August 2025

Accepted: 4 September 2025

First Online: 6 October 2025

Competing interests

: The authors declare no competing interests.

: All animal experiments have been supervised and approved by the Laboratory Animal Ethics and Management Committee of Xiamen University (license number: XMULAC20220098). All patients provided written informed consent. Studies were approved by the Ethics Committee of the First Affiliated Hospital of Xiamen University and conducted in accordance with the principles of the Declaration of Helsinki.

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