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The protective up-regulation of metallothionein-2A in intervertebral disc degeneration inhibits nucleus pulposus cell ferroptosis through activation of the PI3K/AKT/mTOR pathway

Crossref DOI link: https://doi.org/10.1038/s41420-026-02972-9

Published Online: 2026-02-25

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Cai, Hao

Zheng, Huo-liang

Chen, Qi-zhu

Song, Shao-kuan

Yang, Bing-yi

Wang, Yong

Deng, Hui

Mardan, Muradi

Lu, Ze-yu

Chen, Peng-bo

Xu, Qing-yin

Li, Bo

Jiang, Lei-sheng

Zheng, Xin-feng

Jiang, Sheng-dan https://orcid.org/0000-0001-6653-1881
Funding

Funding for this research was provided by:

National Natural Science Foundation of China (82272535)

National Natural Science Foundation of China (82302741)

Shanghai Sailing Program
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Text and Data Mining valid from 2026-02-25

Version of Record valid from 2026-03-06
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Article History

Received: 10 June 2025

Revised: 22 January 2026

Accepted: 16 February 2026

First Online: 25 February 2026

Competing interests

: The authors declare no competing interests.

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