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Inhibiting HSP27 activates the XBP1s/CerS1 interplay, which triggers DRP1-driven mitophagy, thereby protecting against cell death and promoting the KSHV lytic cycle in primary effusion lymphoma cells

Crossref DOI link: https://doi.org/10.1038/s41420-026-02979-2

Published Online: 2026-02-26

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Gonnella, Roberta

Corrado, Vincenzo

Scaffidi, Giulio Francesco

Benedetti, Rossella

Di Crosta, Michele

Zarrella, Roberta

Gilardini Montani, Maria Saveria

Santarelli, Roberta

Cirone, Mara https://orcid.org/0000-0002-2207-9624
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Text and Data Mining valid from 2026-02-26

Version of Record valid from 2026-03-19
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Article History

Received: 29 August 2025

Revised: 21 January 2026

Accepted: 16 February 2026

First Online: 26 February 2026

Competing interests

: The authors declare no competing interests.

: All methods were performed in accordance with the relevant guidelines and regulations. Ethics approval was not needed, as this study does not involve patients or animals.

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