Teng, Weidong https://orcid.org/0009-0009-9610-4317
Guo, Yawen
Ding, Lingling
Zhou, Aoni
Guo, Yehao
He, Jiantong
zhang, Lirong
Yu, Haolan
Tao, Zekai
Wang, Jiafeng
Xu, Jiajie
Tan, Zhuo
Jiang, Liehao
Funding for this research was provided by:
Zhejiang Province Public Welfare Technology Application Research Project (LGF22H160049)
National Natural Science Foundation of China (81702644)
Natural Science Foundation of Zhejiang Province (LY23H160025)
Natural Science Foundation of Zhejiang Province (LY22H168190)
Article History
Received: 13 March 2025
Revised: 18 February 2026
Accepted: 26 March 2026
First Online: 22 April 2026
Competing interests
: The authors declare no competing interests.
: All animal experiments in this study were conducted in strict compliance with the Chinese regulations on laboratory animal welfare and ethical review, and were approved by the Zhejiang Provincial People’s Hospital Animal Ethics Committee (Approval No.: 20240627164644211574). Experimental procedures rigorously followed the internationally recognized “3 R principles” (Replacement, Reduction, Refinement) to minimize the number of animals used and avoid unnecessary suffering. All operations were performed by trained researchers, with appropriate anesthesia and analgesia administered during surgical procedures. Humane euthanasia was implemented at the experimental endpoint.