Chen, Feng
Tang, Tao-Tao https://orcid.org/0000-0003-0220-3285
Chen, Zhi-Qing
Yang, Qin
Zhang, Yue
Zhang, Yi-Lin
Song, Jing
Wang, Meng-Yun
Yang, Hong-Bin
Yang, Min
Qin, Suo-Fu
Guo, Zhe
Wang, Xue-Song
Wang, Zhong
Lv, Lin-Li https://orcid.org/0000-0003-4118-4304
Liu, Bi-Cheng https://orcid.org/0000-0002-4584-1853
Funding for this research was provided by:
National Natural Science Foundation of China (82230022, 82030024, and 81720108007)
National Natural Science Foundation of China (82200772)
National Natural Science Foundation of China (82241045, 82122011)
National Key Research and Development Program of China
Natural Science Foundation of Jiangsu Province (BK20220828)
Shenzhen Science and Technology Innovation Commission (KJZD20230923115201003)
Article History
Received: 6 January 2026
Revised: 26 March 2026
Accepted: 27 April 2026
First Online: 19 May 2026
Competing interests
: The authors declare no competing interests.
: All animal procedures were performed in accordance with the Guide for the Care and Use of Laboratory Animals and approved by the Animal Care Committee of Southeast University. [Approval title: Therapeutic effect of extracellular vesicles derived from human umbilical cord mesenchymal stem cells on renal injury in mice. Approval No.: 20220224039. Date: February 24, 2022]. The work has been reported in line with the ARRIVE guidelines 2.0. The donor of hucMSCs has provided informed consent, and all procedures were approved by Clinical Research Ethics Committee of Zhongda Hospital Affiliated to Southeast University (Approval title: Mechanism study of extracellular vesicles derived from umbilical cord mesenchymal stem cells remodeling inflammatory microenvironment in renal tubule interstitial. Approval No.: 2023ZDSYLL118-P01. Date: May 11, 2023). The work described has been carried out in accordance with Declaration of Helsinki for experiments involving humans.