López-González, Leyre
Becerra-Tomás, Nerea
Babio, Nancy
Martínez-González, Miguel Ángel
Nishi, Stephanie K.
Corella, Dolores http://orcid.org/0000-0002-2366-4104
Goday, Albert
Romaguera, Dora
Vioque, Jesús http://orcid.org/0000-0002-2284-148X
Alonso-Gómez, Ángel M.
Wärnberg, Julia
Martínez, J. Alfredo http://orcid.org/0000-0001-5218-6941
Serra-Majem, Luís
Estruch, Ramon
Bernal-López, M. Rosa
Lapetra, José
Pintó, Xavier
Tur, Josep A. http://orcid.org/0000-0002-6940-0761
López-Miranda, José
Bueno-Cavanillas, Aurora
Delgado-Rodríguez, Miguel
Matía-Martín, Pilar http://orcid.org/0000-0001-9844-3755
Daimiel, Lidia http://orcid.org/0000-0001-9898-6629
Martín-Sánchez, Vicente
Vidal, Josep
Vázquez, Clotilde
Ros, Emilio
Vázquez-Ruiz, Zenaida
Martín-Luján, Francisco M.
Sorlí, José V.
Castañer, Olga
Zulet, M. Angeles
Tojal-Sierra, Lucas
Carabaño-Moral, Rosa
Román-Maciá, Josefa
Rayó, Elena
García-Ríos, Antonio
Casas, Rosa
Gómez-Pérez, Ana M.
Santos-Lozano, José M.
Buil-Cosiales, Pilar
Asensio, Eva M.
Lassale, Camille http://orcid.org/0000-0002-9340-2708
Abete, Itziar
Salaverria-Lete, Itziar
Sayón-Orea, Carmen
Schröder, Helmut
Salas-Salvadó, Jordi http://orcid.org/0000-0003-2700-7459
,
Funding for this research was provided by:
Ministry of Economy and Competitiveness | Instituto de Salud Carlos III (PI13/00728, PI19/00781, PI17/00525, PI13/01056, PI16/01120, PI19/01332, PI13/00272, PI16/01873, PI19/00309, PI13/00673, PI16/00473, PI19/00957, PI13/01123, PI16/01094, PI19/01032, PI14/00636, PI17/01827, PI14/00618, PI17/01183, PI14/01722, PI17/00764, PI14/01374, PI17/01732, PI14/00728, PI17/00215)
Article History
Received: 12 October 2021
Revised: 4 March 2022
Accepted: 14 March 2022
First Online: 11 April 2022
Competing interests
: JS-S serves on the board of (and receives grant support through his institution from) the International Nut and Dried Fruit Council and the Eroski Foundation. He also serves on the Executive Committee of the Instituto Danone, Spain, and on the Scientifc Committee of the Danone International Institute. He has received research support from the Patrimonio Comunal Olivarero, Spain, and Borges S.A., Spain. He receives consulting fees or travel expenses from Eroski Foundation, the Instituto Danone, Spain, Abbot Laboratories, and Mundipharma. ER has received research funding through his institution from the California Walnut Commission, Folsom, CA, USA; was a paid member of its Health Research Advisory Group; and is a non-paid member of its Scientifc Advisory Council. SKN is a volunteer member of the non-for-profit organization called Plant-Based Canada. RE reports grants from Cerveza y Salud, Spain and Fundación Dieta Mediterranea, Spain. Also personal fees for given lectures from Brewers of Europe, Belgium; Fundación Cerveza y Salud, Spain; Pernaud-Ricard, Mexico; Instituto Cervantes, Alburquerque, USA; Instituto Cervantes, Milano, Italy; Instituto Cervantes, Tokio, Japan; Lilly Laboratories, Spain and Wine and Culinary International Forum, Spain and non-financial support to organize a National Congress on Nutrition. Also feeding trials with product from Grand Fountain and Uriach Laboratories, Spain. LL-G, NB-T, NB, MAM-G, DC, AG, DR, JV, AMA-G, JW, JAM, LS-M, FT, JL, XP, JAT, JL-M, AB-C, MD-R, PM-M, LD, VM-S, JV, CV, ZV-R, FM-L, JV-S, OC, MA-Z, LT-S, RC-M, JR-M, ER, AG-R, RC, JS-L, PB, EM-A, CL, IA, IS-L, MC-S and HS have nothing to declare.
: The PREDIMED-plus trial was registered at the International Standard Randomized Controlled Trial (ISRCTN89898870; registration date; 24 July 2014). All participants provided written informed consent, and the study protocol and procedures were approved according to the ethical standards of the Declaration of Helsinki by all the participating institutions: CEI Provincial de Málaga, CEI de los Hospitales Universitarios Virgen Macarena y Virgen del Rocío, CEI de la Universidad de Navarra, CEI de les Illes Balears, CEIC del Hospital Clínic de Barcelona, CEIC del Parc de Salut Mar, CEIC del Hospital Universitari Sant Joan de Reus, CEI del Hospital San Cecilio, CEIC de la Fundación Jiménez Díaz, CEIC Euskadi, CEI en Humanos de la Universidad de Valencia, CEIC del Hospital Universitario de Gran Canaria Doctor Negrín, CEIC del Hospital Universitario de Bellvitge, CEI de Córdoba, CEI del Instituto Madrileño de Estudios Avanzados, CEIC del Hospital Clínico San Carlos, CCEI de la Investigación Biomédica de Andalucía and CCEIC de León. The code of the Ethical Committe aproval of the Cordinated Center (CEIC del Hospital Universitari Sant Joan de Reus) is 13-07-25/7proj2 (approval date: 30/07/2013).