Document is current

Article History

Received: 10 November 2021

Revised: 3 March 2022

Accepted: 22 March 2022

First Online: 11 April 2022

Competing interests

: DSL declares the following conflict of interest: AstraZeneca is funding the French COVAR study coordinated by the Institut Curie and aiming to the classification of <i>BRCA1/2</i> Variants of Unknown Significance. The Department of Genetics of the Institut Curie is performing genotyping (PRS) of MammoRisk®, Predilife. DSL and the Institut Curie have received honorarium for her participation in education meetings organized by AstraZeneca or Tesaro®. RS declares the following conflict of interest: grants or contracts received from AstraZeneca, Amgen. Payment or honoraria received from AstraZeneca, JanssenCilag. Participation on an Advisory Board for AstraZeneca; MSD, GSK, Clovis Oncology. PD reports grants from EU Horizon 2020 program during the conduct of the study. All other authors declare no conflict of interest.

: The study protocol was approved in France by the Comité consultatif sur le traitement de l’information en matière de recherche dans le domaine de la santé (CCTIRS: Consultative committee for information management in health research—No. 16.314) and the Comité de Protection des Personnes Ile-de-France V (CPP—No. 18.12.28.38743 CAT2), in Germany by the Ethics Committee of the University Hospital of Cologne (No. 16-098) and in Spain by the Ethics Committee of the Instituto Catalán de Oncología of Barcelona (No. PR111/16). All recruited women provided written informed consent.